Congratulations! Your answer was correct.
It's C. Risperidone.
Explanation: Hyperprolactinemia may cause impotence, menstrual dysregulation, infertility, and sexual dysfunction. Risk factors for drug-induced hyperprolactinemia include increased potency of dopamine D2 blockade, female sex, and increased age. Additionally, an increased risk is identified in individuals with the cytochrome P450 (CYP450) 2D6*10 allele. Hyperprolactinemia is most likely to occur with risperidone (option C) and high-potency first-generation antipsychotics and least likely to occur with aripiprazole (option D). Quetiapine, ziprasidone, and olanzapine are all less likely to cause hyperprolactinemia than risperidone (options A, B, E). Current American Psychiatric Association guidelines recommend routine monitoring of prolactin serum levels only in symptomatic patients. Treatment strategies include 1) decreasing the dosage of the offending agent, 2) changing medication to an agent less likely to affect prolactin, 3) using a dopamine partial agonist such as aripiprazole, and 4) preventing long-term complications such as bone demineralization.
Muskin PR, ed. Study Guide to Psychiatry: A Companion to the American Psychiatric Publishing Textbook of Psychiatry, Sixth Edition. Arlington, VA: American Psychiatric Association Publishing; 2015: 77, 317. Click here to purchase. Members can purchase at a discount.
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