Academic Stress, Failure May Be Underrecognized Trigger for Suicidal Thoughts, Behaviors

Stressful life events—especially interpersonal rejection and loss and academic failure—are predictive of imminent and near-term suicide risk, said Lisa J. Cohen, Ph.D., a professor of psychiatry at the Icahn School of Medicine at Mount Sinai, at an Annual Meeting session today.

Academic failure stands out as an especially strong correlate with suicide, one that may be frequently overlooked by clinicians, Cohen said.

She reported results from the ongoing Modular Assessment of Risk for Imminent Suicide (MARIS). The study compared psychiatric inpatients and outpatients on the relationship between 22 stressful life events (SLEs) and suicidal thoughts and behavior in the past month and one to two months after their initial assessment. It also compared patient self-reports with retrospective chart reviews.

She was joined in the session by Megan Rodgers, Ph.D., a postdoctoral fellow at Mount Sinai Beth Israel, who presented data from an international study of stressful life events and suicide during the COVID-19 pandemic; and Fredrik Walby, Psy.D., of the University of Oslo, Norway, who presented similar data from the Norwegian Surveillance System for Suicide. The session was chaired by Igor Galynker, M.D., Ph.D., associate chair for research in the Department of Psychiatry at Mount Sinai Beth Israel.

Providing background to the MARIS study, Cohen told attendees that prior research on SLEs and suicide has varied with regard to the populations studied, the SLEs that were considered, and the mode of assessing SLEs.

“Importantly, many studies we found in the literature addressed the total number of SLEs but did not report detailed effects of specific life events on suicide risk,” Cohen said. “Surprisingly, none of these studies included both psychiatric inpatients and outpatients. As psychiatric patients are at grossly elevated risk of suicidal behavior, it is critical to examine the relationship between SLEs and suicide risk in this population. Recently discharged inpatients may be up to 100 times more likely to commit suicide compared with the general population.”

The MARIS study on which Cohen reported included 328 inpatients and 730 psychiatric outpatients recruited from the New York City hospitals in the Mount Sinai hospital system. Patients were assessed with a battery of instruments including the Columbia-Suicide Severity Rating Scale.

The most frequent SLEs were as follows: major financial crisis (n=247), serious problem with neighbor/friend/relative (n=222), breaking off steady relationship (n=153), serious illness of a close friend or relative (n=149), having a serious illness or injury (n=143), academic failure (n=119), and romantic rejection (n=119).

Across all SLEs, the frequency differed between inpatients and outpatients—sometimes markedly: among inpatients, marital separation was more than three times as common; breaking off a steady relationship was twice as common; and academic failure was nearly twice as common. SLEs also differed by self-report and retrospective chart review, in some cases by a factor of 10.

“Clinicians should be aware that there may be a lot going [in a patient’s life] that isn’t going in the medical record,” Cohen said.

The SLEs with the strongest correlation with suicidal thoughts or behaviors within a one-month time frame were breaking off a steady relationship followed by academic failure and romantic rejection. Others SLEs highly correlated with suicidal thoughts and behaviors were serious problems with a friend/neighbor/relative, a period of homelessness, physical abuse or assault by someone close, and financial crisis.

“The most common SLEs, endorsed by over 10% of participants, involved financial crises, interpersonal conflict or loss, serious illness or injury, or academic failure or stressors,” Cohen said. “This is consistent with prior literature, which found financial and interpersonal problems to be the most common stressors associated with suicide thoughts and behaviors. But academic stressors receive far less attention in the literature.”

Cohen said the only predictor of suicide after one month was academic failure. “There is evidence of significant and increasing mental health difficulties in college populations, a growing problem that is not well understood and for which there may be multiple causes,” she said. “Significant academic stressors can represent a potent mental health challenge for young adults with immature coping skills.” ■